Sorry, Readability was unable to parse this page for content.
Source: http://indexation-brigit.blogspot.com/2013/01/recreation-and-sportsswimming-articles.html
october baby sugarland 16 and pregnant ludwig mies van der rohe jamie lynn sigler mega millions jackpot black panther party
Jan. 11, 2013 ? Newly published research by Indiana University structural biologist Joel Ybe and colleagues identifies a "topology switch" in the protein clathrin, the function of which may shed light on molecular processes involved in tumor suppression.
The paper, available in and featured on the front cover of the Jan. 16, 2013, issue of FEBS Letters, a journal of the Federation of European Biochemical Societies, could broaden scientists' understanding of the importance of clathrin and potentially lead to new strategies for controlling cancer.
"This is a totally unexpected but wonderful finding," Ybe said. "It has exciting implications for understanding the role that clathrin may play in the growth or suppression of tumors."
Ybe is a senior research scientist in the Department of Molecular and Cellular Biochemistry in the IU College of Arts and Sciences. Co-authors of the paper are postdoctoral researchers Sarah Fontaine and Xiaoyan Lin; IU chemist Todd Stone; Sanjay Mishra, formerly at IU and now at Vanderbilt University; and Jay Nix of Lawrence Berkeley National Laboratory.
Typically found in a three-legged form called a trimer, clathrin is best understood for its role in endocytosis, the process by which cells absorb proteins and other molecules. But recent research has suggested that clathrin in a one-legged form, or monomer, may have a role in suppressing tumors. Ybe and his team show how a "switch" in clathrin can be flipped to produce non-trimeric clathrin molecules.
"Clathrin is known to function as a trimer in receptor-mediated endocytosis, but the existence of the monomeric form and its role in tumor suppression is less well-accepted," said Alexandra Ainsztein, who oversees membrane trafficking grants at the National Institute of General Medical Sciences of the National Institutes of Health. "By providing evidence for a model in which a molecular shift de-trimerizes clathrin and changes its cellular distribution, this work will spur further research into unanticipated roles for this important molecule in healthy and diseased cells."
In endocytosis, trimeric clathrin molecules bind together to form molecular packages that allow other substances to enter cells. Several years ago, researchers in Japan published evidence that clathrin can also serve as an activator of the protein p53, a known tumor suppressor.
For the activation to take place, clathrin and p53 must both be present in the cell's nucleus. The catch is that clathrin molecules cannot penetrate the nucleus in their usual, three-legged form. To enter, the three-legged clathrin molecule must be altered or "de-trimerized."
Using X-ray crystallography, Ybe and his team discovered a "topology switch" in the clathrin molecule. They showed they could break the switch by mutating one key amino acid that is part of the switch. The result: Clathrin was "detrimerized"; three-legged molecules were broken into one-legged ones.
Experimenting with both cancer and non-cancer cells, the researchers found the three-legged clathrin only in the cytoplasm of the cells, not the nucleus. But with the "switch" broken, clathrin formed monomers and was also present in the nucleus, where it could potentially activate tumor suppression.
Ybe said the results point to the need for additional research to better understand the structure and function of clathrin and the role it plays in cellular processes, including those involved in cancer. With the clathrin "switch" identified, researchers can attempt to better understand how it can be activated, with the goal of developing new therapies for suppressing the growth of tumors. Ybe has a patent pending on the idea to use the mutated form of clathrin to stimulate the natural anti-cancer activities of human cells.
The finding developed from Ybe's research on the role of clathrin in Huntington's disease, a genetic disorder that causes neurological degeneration and is estimated to affect about 15,000 people in the U.S. The National Institutes of Health awarded the project a $1.2 million, four-year grant in 2009. The NIH grant number is R01GM064387.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by Indiana University, via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/e7N4qZGsCk4/130112195735.htm
gingrich wife cheryl burke sarah burke mega upload santorum wins iowa archer ibooks 2
The woman, who cannot be named for legal reasons, suffers from sickle cell disease which has already caused her to have a string of strokes.
Mr Justice Hedley, sitting in the Court of Protection at London's High Court, said the woman, who is 18 weeks pregnant and from the south of England, "manifestly lacked capacity" to participate in legal proceedings at the present time and required the assistance of the Official Solicitor to act as her "litigation friend".
But an independent expert in psychiatry, Dr Stephen Tyrer, expressed the view that she did have capacity "to decide whether or not to continue with, or terminate, pregnancy".
The judge said it was now also the position of all parties and all witnesses that she had capacity, "that being so, the Court of Protection has no jurisdiction to engage in an assessment of her best interests".
He added: "It is right to observe that both expert and professional and family evidence in the case is it would be in her best interests to continue with the pregnancy, but that is outwith the jurisdiction of this court."
The judge said it was very important to bear in mind that people with severe learning difficulties who might not be unable to function independently in the community in other aspects of their lives "may very well retain the capacity to make deeply personal decisions about how they conduct their lives".
These could include decisions about choice of partners, the extent of sexual activity, making permanent relationships "and decisions about their own medical care including, as in this case, the continuation or termination of pregnancy".
Source: http://www.express.co.uk/posts/view/369908/Woman-able-to-decide-on-pregnancy
girl scouts printable bracket game change own stacy francis tournament brackets 2012 ncaa basketball tournament
Standardized testing continues to be a controversial subject in education. On the one hand, it is necessary to assess what students are learning and the effectiveness of instruction. On the other, it is impossible for a single test to accurately reflect the complexities of the education process. One test cannot show the student who hated to write at the beginning of the school year who progressed to independently constructing complete paragraphs. One test cannot show the student who never enjoyed reading who finally found her niche and read five books outside of school this year. One test cannot reflect all those little moments in the classroom that add up to huge individual gains. Further, testing tends to focus only on the subjects of English/Language Arts and Math, thereby ignoring entire subjects in which students may excel. In many districts, standardized test prep courses have taken the places of academic electives like creative writing, public speaking, journalism, and poetry.
Increasingly, student test scores are being tied to teacher evaluations. Which leads to the dilemma of how to assess teachers who teach untested subjects. Unfortunately, the answer is typically to implement more standardized testing. The problem with this is manifold, but primarily rests in the fact that most careers our students will have upon leaving college will require them to be able to think creatively and outside the box. They are jobs in the fields of science and technology that will require students to be able to imagine and create, not just regurgitate rote information and memorized facts.?
Of course, this is a complex dilemma, one that cannot be sufficiently summarized in a short blog entry. My hope is to encourage discourse. We know the problems with standardized testing, but we also know it is necessary to measure student progress. What then are our options? If not standardized tests, then what? I'm looking forward to reading your thoughts.
Source: http://www.mymercurialmusings.com/2013/01/too-much-testing.html
navy jet crash virginia beach isiah thomas passover easter recipes live free or die hard carlos pena amanda bynes arrested
Well, that's exciting! Hardware-maker Nvidia revealed development of an Android-powered handheld game console at a pre-CES press conference tonight. The system, currently going by the name "Project Shield," sports an Xbox 360-like controller with a 5" 720p touch screen attached. Nvidia claims that the internal battery allows for 5-10 hours of gameplay and up to 24 hours of video, putting it on par (if not slightly above) other handheld consoles on the market.
CEO Jen-Hsun Huang said that the handheld system is "pure Android" and showed off several different functions including video playback, social networking, and listening to audio, because it wouldn't be a game console if you couldn't watch <insert currently popular pop song> music videos on it.
Oh, and it plays video games--that's important. Huang showed off a few Android games, including a demo for the upcoming Hawken and some other Android games that looked great on the handheld's Tegra 4 processor. Even more exciting are Project Shield's PC gaming capabilities, which were also shown off (after a few technical hiccups). The system can't actually play PC games, but it can connect to a PC via wireless and stream Steam's Big Picture Mode. This, when mixed with the system's HDMI out capable of outputting 4K resolution, means you can play PC games on your TV with little lag (according to Nvidia), and serves as the link many need to get PC gaming on the television. In short, Project Shield is essentially working like the "rumored" Steam Box console was supposed to.
No price or release date were mentioned outside of the Q2 2013 launch window, but we'll definitely be keeping an eye on what appears to be the most exciting Android-powered game console of the bunch. You can find more information (and more shiny images) on Nvidia's website.
Like what you're seeing?
Sign up for the Newsletter
Here's What You'll Get:
Source: http://www.gamesradar.com/project-shield-revealed-nvidias-android-powered-game-console/
NBA draft 2012 alicia sacramone Don Grady ann curry euro 2012 Colorado Springs pga tour
6 hrs.
New wireless-tracking wristbands designed to make the "Most Magical Place on Earth"?even more hassle-free will hit Walt Disney World in Orlando, Fla., over the next few months.
The "MagicBands" will be linked to customers' credit-card information and function as room keys and park entry passes, thanks to radio-frequency identification (RFID) chips, which are most commonly used in wireless toll collection and public-transit turnstiles.
The MagicBands are part of a bigger system called "MyMagic+," which also allows the theme park to collect sensitive personal information, including names of guests both young and old, their purchasing and riding patterns and real-time location data.
"Imagine booking guaranteed ride times for your favorite shows and attractions even before setting foot in the park," wrote Tom Staggs, chairman of Walt Disney Parks and Resorts, in a blog posting on Monday. "With MyMagic+, guests will be able to do that and more, enabling them to spend more time together and creating an experience that?s better for everyone."
Granular controls
Compared with many companies foraying deeper into the world of data collection, Disney seems to make it very easy for customers to control what and how much information is shared with whom or to opt out of the program completely.
The New York Times reports that, for example, mascot characters could use the information transmitted by the MagicBands to greet visiting children by name ? and even wish them happy birthday if so informed.
But parents could also choose not to share their children's information with park employees in that manner.
The Times said a new part of the official Disney World website, called "My Disney Experience," makes it fairly straightforward to manage MagicBand privacy controls for each member of a family. (There's already a MyDisneyExperience app for iOS and Android devices.)
Parents could share more information about themselves and less about their children, or choose whether to link a credit card to the wristband or simply use it as a ticket to a park or attraction.
Creepy or convenient?
The operation is a huge one. Analysts told the Times that they estimate the cost of installing the system, which will impact 60,000 employees and more than 100,000 guests every day, at somewhere between $800 million and $1 billion.
Some commenters on the StitchKingdom Disney fan site?said they felt "a bit creeped out" and "not terribly comfortable with the idea" in response to an article on MyMagic+ posted in March.
But most commenters there and on other Disney fan sites either thought MyMagic+ was a great idea, or lamented that its users would be able to jump queues ahead of holders of other premium Disney ticket options.
There's no word on when the MyMagic+ program will spread to the four other Disney theme parks in southern California, Japan, Paris and Hong Kong.
More from TechNewsDaily:
Source: http://www.nbcnews.com/travel/travelkit/disney-world-track-visitors-wireless-wristbands-1B7874882
A 114-year-old South Carolina woman who was the oldest living U.S. citizen has died, two of her daughters said Saturday.
Mamie Rearden of Edgefield, who held the title as the country's oldest person for about two weeks, died Wednesday at a hospital in Augusta, Ga., said Sara Rearden of Burtonsville, Md., and Janie Ruth Osborne of Edgefield. They said their mother broke her hip after a fall about three weeks ago.
Gerontology Research Group, which verifies age information for Guinness World Records, listed Mamie Rearden as the oldest living American after last month's passing of 115-year-old Dina Manfredini of Iowa. Rearden's Sept. 7, 1898, birth was recorded in the 1900 U.S. Census, the group's Robert Young said.
Rearden was more than a year younger than the world's oldest person, 115-year-old Jiroemon Kimura of Japan.
"My mom was not president of the bank or anything, but she was very instrumental in raising a family and being a community person," said Sara Rearden, her youngest child. "Everybody can't go be president of a bank or president of a college, but we feel just as proud of her in her role as housewife and particularly as mother and homemaker."
Mamie Rearden, who was married to her husband Oacy for 59 years until his death in 1979, raised 11 children, 10 of whom survive, Sara Rearden said. She lived in the family homestead with a son and a daughter on land that had been in the family since her father's accumulation of acreage made him one of the area's largest black landowners.
Her father sent her off to earn a teaching certificate at Bettis Academy on the far side of the county, spending an entire day on a loaded wagon to reach the school along dirt roads, her daughter said. She taught for several years until becoming pregnant with her third child.
In the mid-1960s at age 65, when some settled into retirement, she learned to drive a car for the first time and started volunteering for an Edgefield County program that had her driving to the end of remote rural roads to find children whose parents were keeping them home from school, Sara Rearden said.
Mamie Rearden always counseled that her children should treat others as they wanted to be treated and that included never gossiping or speaking ill of others. When asked about a preacher's uninspiring sermon, her daughter recalled her mother saying: "'Well, it came from the Bible.' She never would bad-mouth them."
___
Emery Dalesio can be reached at http://twitter.com/emerydalesio
Associated PressChi Magazine Kate Middleton Nude Photos glee glee boxing news Coptic Christian saturday night live
